ࡱ>  Rbjbjqq<ee8O  __8d_(;;(ccck4{'}'}'}'}'}'}'$*4-R'!'__cch'777L_8cc{'7{'77V'#@#c{g# g''0(s#T--##-#7''f(-  %: DN3 NhvuVP[SSO2WVibXhKmՋBRvgIQSMOBgNl lQb/g[gc[SR ,gc[SRe(Wc[lQ3uN[NhvuVP[SSO2WVibXhKmՋBRvgIQSMOBgNl lQ3ubDevQYSdQ Te_N:Nb/g[ċ蕡[ċlQ3ubDecOS0 ,gc[SR/f[NhvuVP[SSO2WVibXhKmՋBRvgIQSMOBgNl vN,Bl 3uN^OncNTvwQSOyr'`nx[vQ-NQ[/f&T(u N(u wQSOt1uSv^vyf[Onc v^OncNTvwQSOyr'`[lQ3ubDevQ[ۏLEQ[T~S0 ,gc[SR/fO3uNT[gNXTO(uvc['`eN FO NSblQ[yb@bmSvL?eNy N N\O:Nlĉ:_6RgbL Yg gYnvsQlĉBlvvQNel _NSNǑ(u FOcO~vxvzDeTDe vsQNXT^(Wu_vsQlĉvMRc NO(u,gc[SR0 ,gc[SR/f(WsLlĉ0hQSO|SS_MRw4ls^ N6R[v @wlĉ0hQv Ne[UTyf[b/gv NeSU\ ,gc[SRvsQQ[_N\eۏLte0 N0V NhvuVP[SSO2Human Epidermal growth factor Receptor 2 HER2 WV[MONgrSO17q12 /fhvuVP[SSOEGFR vbXTKNN HER2WVxRP[ϑ:N185kDavj(lxov;m'`荜|ˆ}v0HER2ˆ}v;NǏN[e-NvQNbXTb_b_NZSO NTꁄvMSO~TS__NZSONMSO~TT o;mj(lxovv;m'`0SN~ހvXk0QNc0@{Tm]{euI{uirf[R0HER2ˆ}vvǏh;N/f1uNHER2WVvibX S[􁿀$v~ހQOSv_8^;mS N$vvSuSU\TOly gsQ0HER2WVvibXTˆ}vvǏhGWSy:NHER23'` `QQsNRSS'`xmm'`sNzLv0ÀSÀTߘ{NLuYLvN N~yÀLv I{`-N0 [Nxmm'`sNzLv^u HER23'`/fcMQu~~Sf[Immunohistochemistry IHC hKm~g:N3+ bSMOBgNelIn situ Hybridization ISH hKm~g:NWVibX0 IHChKm~g:N2+ vuO:N Nnx[ ۏNek^(uSMOBgNelۏLHER2ibXr`vhKm0[NÀLv^u HER23'`/fcIHChKm~g:NHER22+ v TeISHhKm~g:NWVibX bIHChKm~g:NHER23+ 0 [HER23'`vsNzLvTÀLv`ۏLTTbHER2vTluYbHER2USKQbSO0\RP[j(lxovb6RBRI{ O_R`vuX[rQ_0R9eU FO/f(WHER24'`v`-Nl gHeg0Qnx0WhKmHER2ˆ}vhTWVibXr`/fbHER2USKQbSORP[vTlu`[{ TuHeKmvMRc [sNzLvTÀLvv4N^luT/bT$ResQ͑0[Nxmm'`sNzLv^u HER2/f`͑vTch _N/fbHER2oirluv;NKmch0[NÀLv^u HER2/fZfgÀLvvuHeKmh_ir0 ,gc[SR(uNǑ(ugIQSMOBgNelhKmKb/gRd7h,gT;mh7h,gv~~RGr-NvHER2WVibX`Q SbHER2WVs^GWbpeUSOS 0HER2WVs^GWbpeTWV@b(Wv,{17SgrSO@wN|CEP17 ^Rs^GWbpevkfrSMOBgNlChromogenic In Situ Hybridization CISH TX:_SMOBgNlSilver enhanced In Situ Hybridization SISH SRBl N[hQ(ub,ge@bb/gch NYhQb 3uNSN9hncNTyr'`[ N(uRۏLObeEQvQNvċNTDe FO N(uvt1u v^fNelvyf[Tt'`0 ,gc[SR(uNۏL!klQ3ubTvsQSNySfvNT0vQN*g=\N[SbNTΘiRgDeI{ ^S_&{T 0SOYʋeՋBRlQ{tRl 0V[ߘToTvcw{t;`@\N,{5S N N{y 0Rl 0 I{vsQlĉBl0 N0lQ3ubDeBl N ~De ~DevdQ^&{T 0sQNlQ^SOYʋeՋBRlQ3ubDeBlTybQfeNNO Y gvQNfNel ^~vQyf[Tt'`0 1.1WVyr_'`c 1.1.1c^Rvnx[Sbc@b(WWVvMOn:SW N{|WV~e^v[{ 0k[Tyr_nxǏ z0 1.1.2N{|WV~e^KQvt[N,hKmNWV:SWvsQv^RhMOpSTS vX[(W`Q Sb_irv PCRǏ zTNirv5ulV10 1.1.3cvhN,:NvOS^bSf[Tbel ^he_v b0S^SO|TǏ z0Nirv~Se_I{0 1.2@wN|cSb_kSf͑ YUSCQv^R PCR_irvT b gIQgehvS^SO|0Ǐ zTNirv~Se_I{0 1.3cv(ϑc6R'`chN,SbSm^0~^0Tmf:yHER2WVMOphT,{17SgrSO@wN|CEP17 MOphvgIQOSv~ހ`ShQ~ހvkO0 2.yr_'` ;NS fHER2TCEP17c[vh^RƋ+Rvyr_'`0^O(u-NgRˆvvYhT@m]~ހۏLmGrRg0 b5NN Nck8^NvYhT@W{Q~ހmGr7h,g kO7h,g^\hKm20*NgrSORceo}Yv-NgRˆv~ހ [\200*NvMOpۏLRgpe~TgrSOG>f&^Rg ~~ހ8hgrSO NcknxMOpvBgNOS`ShQBgNOSvkO0^O(uhQv~ހW Of[b/gƋ+ROSMOp OYgrSOb_`f[Rg0grSO:Skgr0STDAPIag&^I{b/g[(WHER2WVMOp17q11.2-q12 T/b,{17SgrSO@wN|MOp17q11.2-q11.1 vyr[gIQOS`ShQgIQOSvkO0 3.403'`&{Ts ;NS fNT[ N T{|W7h,g-NHER2WVvhQRTQnx'`0^O(u4N^^(usX-N@b gSv7h,g{|W-NwQ gNh'`v~~{|WۏLċN v^cO7h,gegn0/UNSnnS0ut~~{|W NSfnxvHER2WVibXr`0[N^u:NsNzLvv`Q (uNċNv7h,g{|W^SbsNzxmm'`Lv^yrk{|W0sNzxmm'`\SLv0\{Lv0|mLv o'`uuYzuS~~z$v NSck8^sNz~~I{0[N^u:NÀLvv`Q (uNċNv7h,g{|W^SbW0%_+oW0mTWLaurenRW ÀLv o'`uuYÀ|ba'`pu NSck8^À~~I{0ky~~{|Wn23O7h,gۏLċN0^@w͑ċN3ubNT[IHChKm~g:NHER22+ 7h,gvHER2WVibXr`vhKmR0 4.|[^ 3uN^EQRQ0RMWYhKm|~NSO(usXvV }SbgIQ>f_\vyr_0oSIQnSǏnhVv'`Spe0ir\>e'Y PpeI{ NS N Te00Wp0d\ONXT0hKm!kpe[~g$Rvq_T[hKmKN]_v;NSϑۏL0(uN|[^ċNvST^ bHER2ibX0HER2eibXNS4NLu"V#8%&^'' dWD`gd_' d`gda9 dWD`gda9 d7$8$WD`gda9.!!!T#V#&&()**(5B5666688::<:\;n;;;==APFRHRZZZZZׯׯׯללׯ׏ׯ׍ׯt]t]-h_'ha9B*CJKHOJPJQJaJph0h_'ha9B*CJKHOJPJQJaJo(phUh_'hpzCJ PJaJ %h_'h)LB*CJ KHPJaJ ph(h_'ha95B*CJ KHPJaJ ph%h_'ha9B*CJ KHPJaJ ph%h_'ha9B*CJ KHPJaJ ph)h_'ha9@B*CJ KHPJaJ ph$'()**\,h,...1:12L33*44(5B56788<: pdWD`pgda9$dWD`a$gd_' dWD`gda9 dWD`gd_'<:\;p;^<|<==>?@@AAPPPHQVQHRRSfS@UU~VVVd1$WD`gda9 dWD`gda92.7(Wte*NՋ-N Ջ(uSOYʋeՋBRT[kՋBR^YN gHev(ϑc6R N g'YP^OՋpencvQnx'`SS͑ Y'`04N^ՋxvzeHh-N^fnx(celSMT(u(cՋBRv~Oo`0 3.Ջel 3.1 ] g TTyybQ N^ NT ^ b]ybQ N^ N]~EQRTToirۏL4N^ċNv4OʋeՋBR\O:N[kՋBR f,gTN] N^NTI{He0 3.2eNT (uNÀLvI{vQN(uvdk{|hKmՋBR Ye] N^ T{|NT ^ b4N^Ջ:gg]^zvSel^SbJT$v~ހHER2WVs^GWbpeT$v~ހCEP17s^GWbpe :NSkel ۏLhKm~gvN'`xvz0Sel^]~EQRTToirۏL4N^ċN0 3.3[Ng(u-N]fnxMTwQSOluoir TyvhKmՋBR ^Ǒ(uTToirċN4N^Ջvb__ TeċNhKm~gNcSvTluoirTuHevvsQ'`TՋ(uSOYʋeՋBRhKmvQnx'`0 3.44N^Ջ(u7h,gv bT7h,gϑ 4N^Ջ^ b~10%-N'`Qy\lgV[vw!SW~~7h,gb~~Gr0 ^9hnc[v&{TscShQT [v~f[elR+R{;`7h,gOpeSIHChKm~g:NHER22+ v7h,gOpe0FO;`7h,gOpe NNON1000O0vQ-NIHChKm~g:NHER22+ v7h,g N\N400O0Y3ubՋBRXySN(uNhKm$Nyb$NyN N$v{|W R^(WNy{|Wn NBlvW@x N [kyeXv$v{|WۏL N\N300O7h,gv4N^ IHChKm~g:NHER22+ v7h,g N\N120O07h,gv b^S+T4N^gO(uNTyr_'`7h,g laS+T4N^vsQvTyut~~{|W0 [N^u:Nxmm'`sNzLvv`Q 7h,g^S+T4N^8^vTyxmm'`sNzLvut~~{|W YsNzxmm'`Lv^yrk{|W0sNzxmm'`\SLv0\{Lv0|mLv0yr_'`7h,g^S+TzuS~~z$v0 [N^u:NÀLvv`Q 7h,g^S+T4N^8^vTyzLvut~~{|W YW0%_+oW0mTWLaurenRW 0yr_'`7h,g^S+TÀ|ba'`p0 4.~f[Rg 4.1[4N^Ջ~gv~^ bTv~el0 4.1.1[N,g{|ՋBR 8^NM[RThvb__;`~$NyՋBRv['`hKm~g R+R{hQ7h,gv3'`&{Ts04'`&{TsT;`&{TsNSIHChKm~g:NHER22+ 7h,gv3'`&{Ts04'`&{TsT;`&{Ts0^ bTv~f[hbceelY95%nO:S ~Q Nnx[7h,g`ShQ7h,gvkO v^ċNvQ[&{Tsvq_T Nh$NyՋBRhKm~gvN'`0 4.1.21uNdk{|ՋBR(W4N^~gvbJT-N TebJT$v~ހHER2WVs^GWbpe0$v~ހCEP17s^GWbpeSc(u T$Nvkf_\vMnBl \Sb[v\Nir\v>e'Y Ps0IQnSnIQGrBl0[>f_\MWYPgY\l vBlۏLN~0 6.07h,gBl0 ͑pfnxN NQ[ 6.1[(u7h,gvSPg0V[0SWNRGrvwQSOBl0dkRQ[SSVEbVQvsQhQd\O'`eNQ[ۏLQb_(u0la N T~~{|Wv7h,g^R+Rc0 6.27h,gv3z['`Sb!WWNRGr 0 7.0hKmel0 ~fd\OvT*Nek 7.1fnxhKmvNhVNY0YpGr:g0R`)n{04ltm0gr80BgNvI{0lf'SSuNFUY 0 7.2ՋBRM6Rel0laNy ՋBR_\0M6RTO(uelSlaNyI{0 7.3[NKb]bJSꁨRhKm 1!0nqGr0mS0V[08hxS'`0BgN0mmT YgI{Td\Oek0c^=\ϑ~S fnxTekYte0)n^0laNyYIQ I{Q[0 7.4[BgNT}sGrvPX[S3z['`0 YgTvPX[S3z['`ۏLf0 7.5~f(ϑc6R`Q ^[[k!khKmnQ[gqTY[gq(cGr N[teSOd\OAm zۏL(ϑc6R0ċNch^Sb~ހ~gv[te'` cBgNOSv:_^TMOpvQnx'` ̀ofgIQ:_^ SpeOSUSr/Sr v~ހ`ShQ~ހvkOI{0 7.5.1Q[gqS:NLveck8^~~ fnx7h,ghKmvQ[gqO(uSR Y 75%N Nv$v~ހ8h-N gBgNOSe Ɖ:NhKmbR0 7.5.2Y[gqS b]wHER2WVibXr`v~~RGrb~ހ*h \Sb4NLuk(WNTffN-NNN0 10.1,gՋBRv:NSOYʋeՋBR hKm~gv4N^$R[GW^~T`;SuuSTvQN4N^ʋe~gۏL~Tċ0O N_\O:N4N^ʋlv/UNOnc0 10.2$v~~HER2WVhv_('`Sq_ThKm~g0OYS[IHCNISHhKm0SSvpNlyvp0;mhh,gNKb/gRdh,gvhKm~g NN0_('`(WÀLv-Nf8^0[NÀ\;mhh,g Yp;mh gRNQ\$v_('`vq_T cؚhKmvQnx'`0SY eRluOq_TÀLvHER2r` luMR;mhh,gTluTKb/gh,gv~T$Re gRNf}Yv(uoc[0 10.3,gՋBRvhKm~gS7h,gegn07h,gǑƖǏ z07h,g(ϑ07h,gЏagN07h,gYtI{V }q_T0 Te1uN~g$Rev;N‰'` S[_QGP3'`bGP4'`vhKm~g O(u^NhKmǏ z-NSX[(Wv\o(W[~g NQnxI{@\P'`0 10.4hKm~gYN~~utf[yr_ N&{ ^8h[utʋeb͑ehKm0 10.5,gNTv'`ch/fWNffN@bhKm z^_ [ z^ۏLf9e SO9eShv~g0 10.6,gՋBRN[~10%-N'`Qy\lgV[w!SWv~~ۏLNY(u N_(uNvQN7h,g{|WbAm_~ހhKmI{vQN(u0 11.0NT'`ch0 9hncRg'`ċ0Oxvz~g N N'`ch SbxvzelTċ0O~g 11.1upOe^(WsNzxmmLv/ÀLvuOv~~7h,g NSLveck8^~~bo'`uu~~7h,g-NcNvhWVMOpv~THes0 11.2yr_'`HER2TCEP17c[vh^RƋ+Rvyr_'`0 11.3403'`&{Ts(W N T~~{|W-NHER2WVvhQRTQnx'`0 11.4|[^ybQ0yb|[^S N Te00Wp0hKm|~Y(u 0NXTKNv|[^0 11.54N^Ջpenc;`~0 12.0laNy0 12.1 gsQՋBRvQNn~RY g uir[hQ'`vfJT0 12.2 gsQ[d\O-NmSՋBRv[hQ'`c:y Sb[ gk g[ir(v2bSqSiirTvYtelI{0 12.3gIQge(WIQgqagN N[fmmp0:NMNOq_T [@b g+TgIQcvnm SbBgNT7h,g}sGrGW^=\ϑMQbQ\(WIQgqagN NOX[TYt0 12.4O(u!hQǏv)n^Km[nm04ltmiT)n{)n^0 N0QUSMO V[ߘToTvcw{t;`@\;SuhVhb/g[ċ-N_0       PAGE \* MERGEFORMAT2   PAGE \* MERGEFORMAT1   VX8ZZZZZZZ [$dp$Ifa$gd_'m$ $da$gd_'m$dWD`gda9m$ dWD`gda9 ZZZZZZZZZ[ [ [[[[[ ["[&[.[0[4[:[@[H[J[P[R[V[X[`[b[h[j[n[p[x[z[[[[[[[[[[[кгyy"h ]B*CJKHPJaJo(ph%h[ha9B*CJKHPJaJph(h[ha9B*CJKHPJaJo(ph hVha9*ha9B*CJKHOJPJQJaJo(ph-h[ha9B*CJKHOJPJQJaJph0h[ha9B*CJKHOJPJQJaJo(ph/ [ [[[[[[H::::: dp$Ifgd_'m$kd$$IfTlr+ "9!  t0!44 layt3T[ ["[([*[,[.[G99999 dp$Ifgd_'m$kd$$IfTl4r+ "9!`  t0!44 layt3T.[0[6[B[D[F[H[G99999 dp$Ifgd_'m$kd$$IfTl4r+ "9!   t0!44 layt3TH[J[L[Z[\[^[`[G99999 dp$Ifgd_'m$kdn$$IfTl4r+ "9!`  t0!44 layt3T`[b[d[r[t[v[x[G99999 dp$Ifgd_'m$kd>$$IfTl4r+ "9!   t0!44 layt3Tx[z[|[[[[[G99999 dp$Ifgd_'m$kd$$IfTl4r+ "9!   t0!44 layt3T[[[[[[[G99999 dp$Ifgd_'m$kd$$IfTl4r+ "9!   t0!44 layt3T[[[[[[[G99999 dp$Ifgd_'m$kd$$IfTl4r+ "9!`  t0!44 layt3T[[[[[[[[[ \\ \"\0\2\8\@\N\P\^\`\f\h\r\t\z\\\\]]]]]H^J^V^X^t_z_~_______`&`(`.`Ѿ)h@ha9@B*CJ KHPJaJ ph)h3ha9@B*CJ KHPJaJ ph%h3ha9B*CJ KHPJaJ ph%h@ha9B*CJ KHPJaJ ph hVha9%h[ha9B*CJKHPJaJph(h[ha9B*CJKHPJaJo(ph2[[[[[[[G99999 dp$Ifgd_'m$kd~$$IfTl4r+ "9!   t0!44 layt3T[[[[[[[C55555 dp$Ifgd_'m$kdN$$IfTl4r+ "9!   t0!44 laf4yt3T[[[\\ \ \G99999 dp$Ifgd_'m$kd+$$IfTl4r+ "9!`  t0!44 layt3T \\\\\\ \G99999 dp$Ifgd_'m$kd$$IfTl4r+ "9!   t0!44 layt3T \"\$\*\,\.\0\G99999 dp$Ifgd_'m$kd $$IfTl4r+ "9!   t0!44 layt3T0\2\B\H\J\L\N\G99999 dp$Ifgd_'m$kd $$IfTl4r+ "9!   t0!44 layt3TN\P\R\X\Z\\\^\G99999 dp$Ifgd_'m$kdk $$IfTl4r+ "9!`  t0!44 layt3T^\`\b\l\n\p\r\G99999 dp$Ifgd_'m$kd; $$IfTl4r+ "9!   t0!44 layt3Tr\t\\]]G22$ dWD`gda9$d7$8$H$WD`a$gda9kd $$IfTl4r+ "9!   t0!44 layt3T]J^X^__aaabclccc*dBddd@eee&fBfDgVggghii dWD`gda9.```aaa&aPaXanaxaaaaaaabbccjclc~cccccc(d*d@dBddddd>e@eeeee$f&f@fBflfrfvf|fBgDgTgVgggg¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯%h3ha9B*CJ KHPJaJ ph%h@ha9B*CJ KHPJaJ ph%h3ha9B*CJ KHPJaJ ph)h@ha9@B*CJ KHPJaJ ph)h3ha9@B*CJ KHPJaJ ph9gghhhhhh(i*iiiiijjjjjjnkpkkkkkkkkkkk$l&lHlJlnlplmmmm6n8nHnNnnnnnnnnnnnƳ٠ٍ%h3h ]B*CJ KHPJaJ ph%h@h ]B*CJ KHPJaJ ph%h3ha9B*CJ KHPJaJ ph%h@ha9B*CJ KHPJaJ ph%h3ha9B*CJ KHPJaJ ph%h@ha9B*CJ KHPJaJ ph7ijpkkkplm8nno`prpq4qqqbr|rr$dG$H$WD`a$gda9dH$WD`gda9$dH$WD`a$gda9 Xd^Xgda9 d7$8$WD`gda9 dWD`gda9n~oooo^p`ppprpqq2q4qqqqqqq`rbrzr|rrsssssssssLtNtttvttttt u uPuRuuuvZv\v w w,w.wvwxwwwwwx(h@ha95B*CJ KHPJaJ ph( *h@ha9B*CJ KHPJaJ ph%h3h B*CJ KHPJaJ ph%h@ha9B*CJ KHPJaJ ph%h3ha9B*CJ KHPJaJ ph=rssssNtvttt uRuu>v\v.wwxyzz\{t{||Fb dWD`gd_' dWD`gda9xx&y.yyyzzzzzz{{{{"{,{Z{`{r{t{||||||*},}F}J}x}z}}}}}}}}~~~~~~"~*~0~\~`~l~t~z~~~~~~~~~~~~~~~~~ٳٳٳ%h3h ]B*CJ KHPJaJ ph%h3h)LB*CJ KHPJaJ ph%h3ha9B*CJ KHPJaJ ph%h@ha9B*CJ KHPJaJ phF~~~~DF`bFH~Āʀ̀Ҁԁց\^rxփ؃ރ<>Z\Ƅ΄Єڄ (@Bʅ̅ٳٳٳ%h3huB*CJ KHPJaJ ph%h3h)LB*CJ KHPJaJ ph%h3ha9B*CJ KHPJaJ ph%h@ha9B*CJ KHPJaJ ph@ց^>B̅b(6fhjgd[ $d1$a$gda9d@&WD`gda9$dWD`a$gda9 dWD`gda9`b&(046dfhjlnrtxz~ƹre]Y]Y]Y]YH h_'hVB*CJaJo(phh4jh4Uh_'hpzCJ PJaJ h_'h[CJ PJaJ %h5ha9B*CJ KHPJaJ phh@ha9CJ PJaJ h3ha9CJ PJaJ h@ha9CJ PJaJ h3ha9CJ PJaJ %h@ha9B*CJ KHPJaJ ph%h3ha9B*CJ KHPJaJ ph%h3h B*CJ KHPJaJ phjlprvx|~‡ćƇ  $4$a$gdN $4$a$gd_'h]hgdN @d WDd`@gd[‡ćƇʇ̇ ٷٛ~h_'hpzCJ PJaJ h;%h ]h4hv hNhN h_'hVB*CJaJo(phh zh)h ]hc2CJaJo(#h[h[CJaJmHnHsHuh_'hVCJaJjh_'hVCJUaJh_'hVCJaJo(:&P 182P:p_'. A!"#$%S $$If!vh55 555#v#v #v#v:V l t0!,55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!)v+55 55f4yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3T$$If!vh55 555#v#v #v#v:V l4 t0!+55 55yt3Tb# 00000000002 0@P`p28 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~PJ_HmH nHsH tHJ`J cke $1$a$ CJKH_HaJmH nHsH tH$A $ ؞k=W[SOBi@B nfh*B*phXX 0e0msolistparagraphWD`OJ QJ ^J aJ, , 0e0`SMO&{e,g B*ph(' ( 0e0ybl_(uCJaJ: : 0e0ybleW[$a$aJmHsHtH6/6 0e0 ybleW[ Char CJKHaJ6j 6 !0e0ybl;N 5\mHsHtH</< 0e0 ybl;N Char5CJKH\aJ@ "@0e0O" CJKH_HaJmH nHsH tHPK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!mQtheme/theme/theme1.xmlYMoE#F{oc'vGuرhF[x=ޝzvg53NjHHzZ $ʯI)*E_N&IA!>Ǽ3xN>鱫WL0Č߫߿z}rx{h9T8T/χ?xY'~3S~O_|w)ӈHt=a+d NG1-RlƁ1RJwT蠯M1K"o he˓ێ½PL-|%EhY7'qP.\L=dqķ3Iofi.ñBRb-JP_pG ݢiKtdӌhFio7;7Q2ȾD>a/Q>XW ˔M_uHq)h +:Viw4rBqϫ"r!2laCbU|!8^8>ܠ,AбVt׎~ls14_=,ɬožTV G"ѦbH'.4x޵w-ϷE|F;v`b3"G 'e\fHO '$i_wp >*8i&LY%\,xҕ= r6f 3Tʅ):ªZKLs&C Mܛ0 [˫p@ע`j۽7 YHxHicT5Ar@HZAZC}i' RQ\m,zo,gQu{Y\,Nר/=L _.̇Y7C6-fSh62"5NHT[X65̫4X%Yֳ2fkhi~tCKF#b +w1m|4`!:U!p5a:~{4mmio ήc8mDJpSǹ橠V1?#Si?3E'pS2W`qB]( 08w nA[s)k8= Aa?R dڒɾcUӽ˲d)#Queb}C!&i0>4S7{z F} 4sKvUKoȳh~1jYUVH5U8Vk;֜L9ŰD ?*|FL "A3>]2ֵ褽mg 88  -NNNQBZ[.`gnx~!#%FOZ[]_`bdl'<:V [[.[H[`[x[[[[[[ \ \0\N\^\r\]irj"$&'EGHIJKLMNPQRSTUVWXY\^ac%'/EGQ!!t  ,b$Gd3_`G@ߜ>;@H 0(  0(  B S  ?8 _Toc323285333 _Toc323285335 _Toc323285336 OLE_LINK22 OLE_LINK16 OLE_LINK176k%I2I28Br%o2o2888888888888+""" #6688888888888888888888888--Q Q 88+"+"z"{"""""""""""-,-,0,0,a,a,3344&4&4<4<488888888888888888888~%ȖrWWm[ac5hh^h`o(.H\H^H`\)\^`\.\^`\.4\4^4`\) \ ^ `\.| \| ^| `\. \ ^ `\)\^`\.% 0P0^0`POJQJ^Jo(. \^`\hH) l\l^l`\hH.  \ ^ `\hH.  \ ^ `\hH) X \X ^X `\hH.  \ ^ `\hH. \^`\hH) D\D^D`\hH.~%Wm[acd                YoT5ni]x'mnUkPlw yMxB )  z p4X}Pb]e}?%g,,IV?iK VO!$$;%_'X'}'j( Q*S*(+o+,/qu1G20355/5k26I8x*:/E;/<6J<=|>Z";icHܲr'2%ڳg iAl^=mnCnurFPsYtovxdxrxby@{r|@blDY IVW5<W-F^t'#1m)byF;+b}C[i)-e|:NT Q)b#F[ (,u63-4)3erd 8XvN:[q Wn7`rxoP+!+je D z2?Dbl#"jd:rc2BC\6)LZ%p v7a91 ;zP3pzvGKbc[h`nn2Y">DMuRd88@88X888hhPUnknown G*Ax Times New Roman5Symbol3" Arial;= |8ўSOSimHei;5 N[_GB23121NSeN[7E eck\h[{SO;5 wiSO_GB2312;([SOSimSun7.@ CalibriA$BCambria Math!1h\\p0fp0f-!),.:;?]}    & 6"0000 0 0 00000 =@\]^([{  0 0 00000;[irl8l83qHX?`2! xx@\Se_7h Xtzj.UserUSER   Oh+'0P     $08@Hַʽ Xtzj.UserNormalUSER2Microsoft Office Word@F#@ jy@2{@2{p0՜.+,0 X`t|  Xtzj.Comfl8   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdeghijklmopqrstuvwxyz{|}~Root Entry F{Data f1Tablen-WordDocument <SummaryInformation(DocumentSummaryInformation8MsoDataStoreP{{NKSS1U21DD==2P{{Item  PropertiesUCompObj e   F#Microsoft Office Word 97-2003 ĵ MSWordDoc9q